Cancer of the Breast—by Janet Lane-Claypon (1926): A Reanalysis
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Increased Risk of Breast Cancer in Multiparous and Lactating Women in Pakistan: A Paradigm Shift?
Breast cancer is the most commonly diagnosed cancer in women world wide (Parkin and Whelan, 2000). A rapid rise in annual incidence rate of breast cancer has been observed between 1975-1990 in Asian and African than North American and European women (Sasco, 2001). The published data from Karachi Cancer Registry, the reported incidence of breast cancer was 34.6% and observed as the most common c...
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It has long been known that the risk of breast cancer shows an inverse relationship with parity (Lane Claypon, 1926). The credit for obtaining a proper understanding of the nature of this relationship, however, must go to MacMahon and his colleagues who, in the late 1960's, conducted a collaborative case-control study in seven parts of the world with markedly different breast cancer rates (MacM...
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Since the early twentieth century a large evidence and knowledge base of risk factors for breast cancer has developed. The seminal study of breast cancer epidemiology was the Lane–Claypon report in 1926.[1] This study was important not only in the etiology of breast cancer but also in the development of epidemiological methods, being arguably the first systematic case-control study. Before revi...
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In the summer of 1924, an outbreak of scarlet fever occurred in Flint, Michigan. Unable to trace it to the usual causes, particularly fresh milk, the Michigan Department of Health used a novel approach to disentangle the enigma: The 116 cases of scarlet fever were compared with 117 “controls” selected from neighbors of the quarantined cases and from patients at the City Health Center who had be...
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